Current Issue : October - December Volume : 2020 Issue Number : 4 Articles : 6 Articles
Metastatic lung tumours rarely lead to development of pneumothorax, and\nno case of bilateral secondary pneumothorax due to lung metastases arising\nfrom tongue cancer has been reported. Here, we report a case of a patient\nwith tongue cancer with lung metastases complicated by bilateral secondary\npneumothorax soon after the completion of concurrent chemoradiotherapy.\nA 39-year-old man with cervical lymph node metastases originating from\npT2N0M0 tongue cancer underwent neck dissection and postoperative concurrent\nchemoradiotherapy. Shortly after the completion of chemoradiotherapy,\nhe developed bilateral secondary pneumothorax. Subsequently, he underwent\npartial lung resection for the pulmonary fistulae for diagnostic and\ntherapeutic purposes; nodular lesions found in both the lungs. The diagnosis\nof secondary pneumothorax was based on histopathological findings. Although\nall pulmonary fistulae disappeared after partial lung resection, he died\nof the primary disease despite our best efforts to control the metastatic pulmonary\nlesions....
Prognosis prediction of squamous cell carcinoma (SCC) with mandibular invasion is\ncontroversial, and a more sophisticated staging system to aid prognosis could be developed with\nimaging characteristics of bone invasion. Imaging-feature analysis provides practical, stratified\nresults for survival prognosis in oral SCC (OSCC) of the mandible, and imaging advances enable\nmore detailed tumor visualization. We retrospectively evaluated significant bone-invasion features\nassociated with poor outcomes in mandibular OSCC to assess the predictive value of staging criteria\nthat combined imaging features and histologic grade (combined imagingâ??histology (IH) grade) in\n65 patients (39 men, 26 women) with mandibular SCC diagnosed from 2006 to 2016.\nClinicopathologic features, including T-stage and histologic grade, and prognosis were retrieved.\nTumors were classified into three types by extent of mandibular invasion on pretreatment imaging\nstudies. Moreover, we assessed the involvement of the mandibular canal. We examined the\ncorrelation of factors associated with locoregional recurrence and overall mortality. The Harrell\nConcordance Index (C-index) determined prognostic performance of predictors. Nineteen (29%)\npatients showed locoregional recurrence and 13 (20%) died. For locoregional recurrence and\nmortality rates, imaging-detected mandibular canal (MC) involvement is a stronger prognostic\nfactor for recurrence............................
Estrogen receptor Alpha (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in\nthe development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region,\nconnecting the ligand binding and DNA domains. rs142712646 is a rare SNP in ESR1, which leads to a substitution\nof arginine to cysteine at amino acid 269 (R269C). The mutation is positioned in the hinge region of ESR1, hence\nmay affect the receptor structure and function. We aimed to characterize the activity of R269C-ESR1 and study its\nrole in the development of pancreatic cancer....................
We performed a descriptive retrospective study of sexual and urinary disorders\nafter treatment of rectal cancer by radiotherapy and/or surgery at the\nDantec University Hospital in Dakar from 2008 to 2015. The objective of the\nstudy was to evaluate these sexual and urinary complications and the factors\ninfluencing it. We have collected 50 patients. The average age of is 55.7 years\nwith a sex ratio of 0.78. The dominant clinical signs are rectorrhagia (66.0%).\nEndoscopy (94.0% of patients) showed an ulcerative-budding appearance in\n84.0% of cases. The preferred location was the lower rectum 66.0%). The\npredominant histologic type is adenocarcinoma lieberkunien (82.0%). Computed\ntomography is performed in 78% of cases and MRI in 30%. Stage III\naccounts for 70.0% of cases. Thirty-two patients (64.0%) were treated with\nconventional 2-beam 2D radiation therapy with or without chemotherapy.\nThe total dose of 46 Gy in 23 sessions was the most used, found in 22 patients;\n30 Gy in 10 sessions in 9 cases. And 16 Gy in 10 sessions, found in 1\ncase. Surgery performed was abdominoperineal amputation (58.0%) and\nconservative surgery (42.0%). We note a complete response in 28.0% of patients;\n8.0%, an increase of 16.0% and a stabilization of 4.0%. The sexual disorders\nare more important after radiotherapy compared to non-irradiated patients:\n31.3% vs 5.6% (p = 0.035). We observe respectively that 2%, 6% and\n8% of our patients had urinary disorders in the form of acute retention, urinary\nincontinence, and urinary burning. Patient follow-up time was between\n0 and 42.83 months with an estimated average of 34.9 ± 3.37. The evolution is\nmarked at 6 months by a persistence of sexual disorders in 63.8% of cases and\nurinary dysfunction in 4% of cases....
Accurate diagnosis of early lung cancer from small pulmonary nodules (SPN) is challenging in clinical\nsetting. We aimed to develop a radiomic nomogram to differentiate lung adenocarcinoma from benign SPN.\nMethods: This retrospective study included a total of 210 pathologically confirmed SPN........................
Immunotherapy has become an essential part of cancer treatment after showing great efficacy in\nvarious malignancies. However, its effectiveness in pancreatic ductal adenocarcinoma (PDAC), especially in\nresectable pancreatic cancer, has not been studied. The primary objective of this study is to compare the OS impact\nof immunotherapy between PDAC patients who receive neoadjuvant immunotherapy and patients who receive\nadjuvant immunotherapy. The secondary objective is to investigate the impact of neoadjuvant and adjuvant\nimmunotherapy in combination with chemotherapy and chemoradiation by performing subset analyses of these\ntwo groups.\nMethods: Patients diagnosed with PDAC between 2004 and 2016 were identified from the National Cancer\nDatabase (NCDB). Multivariable Cox proportional hazard analysis was performed to examine the effect of\nneoadjuvant and adjuvant immunotherapy in combination with chemotherapy and chemoradiation on the OS of\nthe patients. The multivariable analysis was adjusted for essential factors such as the age at diagnosis, sex, race,\neducation, income, place of living insurance status, hospital type, comorbidity score, and year of diagnosis.......................
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